Anti-citrulline antibody, also known as anti-citrullinated protein antibody (ACPA), is an autoantibody that targets citrulline, an amino acid produced during post-translational modifications of proteins.
Se cachad version
Anti-citrulline antibody, also known as anti-citrullinated protein antibody (ACPA), is an autoantibody that targets citrulline, an amino acid produced during post-translational modifications of proteins.
Se cachad version
Protein citrullination (PC) is a posttranslational modification (PTM) that converts a peptidyl arginine into a peptidyl citrulline. Aberrant PC is a hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease, prion disease, and multiple sclerosis.
Se cachad version
Citrullination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. This process is catalysed by enzymes called peptidyl arginine deiminase (PAD) and arginine deiminases (ADIs). PADs replace the primary ketimine group (>C=NH) with a ketone group (>C=O).
Se cachad version
Peptidyl arginine deiminase 4 (PAD4) is a post-translational modification enzyme that converts positively charged arginine residues in protein substrates to neutral citrulline, via a process termed deimination or citrullination [1].
Se cachad version
Technological and scientific advances have revealed broad clonal diversity and intriguing features including high levels of somatic hypermutation, variable-domain N-linked glycosylation,...
Se cachad version
Our results show that citrulline strengthens the interaction between vimentin and the HLA-DRB1 molecules, therefore impacting both the peptide affinity to the HLAs and pHLA stability; it also induces more intermolecular hydrogen bond formation during MD in the pHLA.
Se cachad version
Using HLA-DR4-tetramers, we examine the T cell repertoire in HLA-DR4 transgenic mice and observe biased TRAV6 TCR gene usage across these two citrullinated epitopes which matches with TCR bias...
Se cachad version
The immune system produces anti-citrullinated protein antibodies (ACPAs) to target citrullinated proteins. ACPAs can help doctors diagnose early rheumatoid arthritis (RA) and predict how likely it ...
Se cachad version
These antibodies are detected in the laboratory using artificial cyclic citrulline peptides (anti-CCP Ab).This assay is far more sensitive and specific than rheumatoid factor for the diagnosis of rheumatoid arthritis and some childhood arthritides.
Se cachad version
Methods Our study investigates the immunological roles of extracellular vimentin (eVim) and its citrullinated form (CitVim) as a damage-associated molecular pattern (DAMP) engaging the Toll-like receptor 4 (TLR4) of human neutrophils.
Se cachad version