Early Life Adversity, Microbiome, and Inflammatory Responses - MDPI www.mdpi.com/2218-273X/14/7/802Private View Early life adversity has a profound impact on physical and mental health. Because the central nervous and immune systems are not fully mature at birth and continue to mature during the postnatal period, a bidirectional interaction between the central nervous system and the immune system has been hypothesized, with traumatic stressors during childhood being pivotal in priming individuals for ...