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https://en.wikipedia.org/wiki/Citrullination
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Citrullination - Wikipedia
Citrullinated peptides and proteins can be detected using antibodies targeting the citrullinated residues, or detected using mass spectrometry-based proteomics technologies. Citrullination of arginine results in a monoisotopic mass increase of +0.984016 Da, which can be measured with mass spectrometry..
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Citrullination - Wikipedia

Citrullinated peptides and proteins can be detected using antibodies targeting the citrullinated residues, or detected using mass spectrometry-based proteomics technologies. Citrullination of arginine results in a monoisotopic mass increase of +0.984016 Da, which can be measured with mass spectrometry..

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https://www.nature.com/articles/s41594-024-01214-9
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A quantitative and site-specific atlas of the citrullinome reveals ...
probability (>0.9) (Extended Data Fig. 2c), thereby ensuring high confidence in distinguishing between amino acids that become citrullinated or deamidated. The average localization probability of ...
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A quantitative and site-specific atlas of the citrullinome reveals ...

probability (>0.9) (Extended Data Fig. 2c), thereby ensuring high confidence in distinguishing between amino acids that become citrullinated or deamidated. The average localization probability of ...

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https://pmc.ncbi.nlm.nih.gov/articles/PMC6899306/
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An Overview of the Intrinsic Role of Citrullination in Autoimmune ...
The products of this process are citrullinated proteins, which contain a nonessential amino acid, citrulline. The immune system can recognize the deiminated or citrullinated proteins as nonself-antigens and so mount an autoimmune response.
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An Overview of the Intrinsic Role of Citrullination in Autoimmune ...

The products of this process are citrullinated proteins, which contain a nonessential amino acid, citrulline. The immune system can recognize the deiminated or citrullinated proteins as nonself-antigens and so mount an autoimmune response.

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https://www.nature.com/articles/s41467-020-20279-w
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Site-specific incorporation of citrulline into proteins in mammalian ...
of protein citrullination remain challenging due to the difficulty of accessing proteins homogeneously citrullinated at a ... specific incorporation of unnatural amino acids (UAAs) into proteins ...
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Site-specific incorporation of citrulline into proteins in mammalian ...

of protein citrullination remain challenging due to the difficulty of accessing proteins homogeneously citrullinated at a ... specific incorporation of unnatural amino acids (UAAs) into proteins ...

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https://pmc.ncbi.nlm.nih.gov/articles/PMC8788905/
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Citrullination in the pathology of inflammatory and autoimmune ...
When immune tolerance to citrullinated proteins is lost, anti-citrullinated proteins antibodies (ACPAs) are produced that recognize the newly formed epitopes []. ACPAs are detected in 75% of RA patients, and, therefore, their detection is used as a predictive method before disease onset as they are present in the serum of patients even 5 years prior to the symptomatic phase of the disease [ 3 ].
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Citrullination in the pathology of inflammatory and autoimmune ...

When immune tolerance to citrullinated proteins is lost, anti-citrullinated proteins antibodies (ACPAs) are produced that recognize the newly formed epitopes []. ACPAs are detected in 75% of RA patients, and, therefore, their detection is used as a predictive method before disease onset as they are present in the serum of patients even 5 years prior to the symptomatic phase of the disease [ 3 ].

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https://www.nature.com/articles/s41467-023-36620-y
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Citrullination modulates antigen processing and presentation by ...
Citrullination induces both proximal and distal changes in processing relative to citrullinated sites in the linear amino acid sequence To investigate the relationship between citrulline residues ...
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Citrullination modulates antigen processing and presentation by ...

Citrullination induces both proximal and distal changes in processing relative to citrullinated sites in the linear amino acid sequence To investigate the relationship between citrulline residues ...

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https://pmc.ncbi.nlm.nih.gov/articles/PMC5101001/
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Citrullination in Rheumatoid Arthritis—A Process Promoted by ...
Abstract Anti-citrullinated protein antibodies (ACPAs) are highly specific serologic markers for rheumatoid arthritis (RA) and can pre-date clinical disease onset by up to 10 years, also predicting erosive disease. The process of citrullination, the post-translational ...
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Citrullination in Rheumatoid Arthritis—A Process Promoted by ...

Abstract Anti-citrullinated protein antibodies (ACPAs) are highly specific serologic markers for rheumatoid arthritis (RA) and can pre-date clinical disease onset by up to 10 years, also predicting erosive disease. The process of citrullination, the post-translational ...

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https://www.sciencedirect.com/science/article/pii/S13572725060009...
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Citrullination: A posttranslational modification in health and disease
Peptide-bound arginine residues can undergo this modification and the resulting citrulline remains part of the protein as peptidyl citrulline. Citrulline is not a natural amino acid in proteins, therefore may induce immune response. The importance of citrullinated ...
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Citrullination: A posttranslational modification in health and disease

Peptide-bound arginine residues can undergo this modification and the resulting citrulline remains part of the protein as peptidyl citrulline. Citrulline is not a natural amino acid in proteins, therefore may induce immune response. The importance of citrullinated ...

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https://www.longdom.org/open-access/optimizing-the-identification...
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Optimizing the Identification of Citrullinated Peptides by Mass ...
Optimizing the Identification of Citrullinated Peptides by Mass Spectrometry: Utilizing the Inability of Trypsin to Cleave after Citrullinated Amino Acids Tue Bennike 1 *, Kasper B. Lauridsen 1, Michael Kruse Olesen 2, Vibeke Andersen 3, 4, Svend Birkelund 1 and Allan Stensballe 1 ...
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Optimizing the Identification of Citrullinated Peptides by Mass ...

Optimizing the Identification of Citrullinated Peptides by Mass Spectrometry: Utilizing the Inability of Trypsin to Cleave after Citrullinated Amino Acids Tue Bennike 1 *, Kasper B. Lauridsen 1, Michael Kruse Olesen 2, Vibeke Andersen 3, 4, Svend Birkelund 1 and Allan Stensballe 1 ...

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https://en.wikipedia.org/wiki/Anti%E2%80%93citrullinated_protein_...
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Anti–citrullinated protein antibody - Wikipedia
Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these antibodies in patient serum or plasma (then referred to as anti–citrullinated peptide antibodies). [ 1 ] During inflammation, arginine amino acid residues can be enzymatically converted into citrulline residues in proteins such as vimentin , by a process called citrullination .
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Anti–citrullinated protein antibody - Wikipedia

Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these antibodies in patient serum or plasma (then referred to as anti–citrullinated peptide antibodies). [ 1 ] During inflammation, arginine amino acid residues can be enzymatically converted into citrulline residues in proteins such as vimentin , by a process called citrullination .

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citrullination
Citrullinated peptides and proteins can be detected using antibodies targeting the citrullinated residues, or detected using mass spectrometry-based proteomics technologies. Citrullination of arginine results in a monoisotopic mass increase of +0.984016 Da, which can be measured with mass spectrometry.. Wikipedia
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